Machine learning identifies clinical tumor mutation landscape pathways of resistance to checkpoint inhibitor therapy in NSCLC.

J Immunother Cancer · 2025 · PMC11877243 · PMID 40032600

Europe PMC DOI

hedged sentence

0.0560

closest p · 1.1× alpha

0.0560

boldest claim

The sentences

only marginally significantp=0.056so close (0.05 < p ≤ 0.1)

Although the top triplet mutations in KRAS, NF1 and TP53 showed a significant substantial increase in OS (p=0.00041) in the 1,150-patient cohort, the increase was only marginally significant (p=0.056) in the larger CPI-treated cohort ( figure 4C and online supplemental figure S2C ).

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