4-Hydroxychalcone attenuates AngII-induced cardiac remodeling and dysfunction via regulating PI3K/AKT pathway.

We observed that the elevation in SBP was also reduced in 4-HCH (40 mg/kg)-treated mice compared to vehicle controls following Ang II infusion; however, this difference did not reach statistical significance (Fig. 4a ).The heart rate was also not significantly different among the groups (Fig. 4b ).

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