Validation of a breast cancer assay for radiotherapy omission: an individual participant data meta-analysis.

Analysis of tumor specimens from each of these 3 RCTs demonstrated that POLAR was prognostic for locoregional recurrence in the no RT arms, although this analysis did not reach statistical significance in the smaller Princess Margaret dataset. 27 When tumor samples were dichotomized as POLAR high vs POLAR low using the predefined cutoff, all 3 trials demonstrated the expected benefit of RT among women whose tumors were POLAR high but no statistically significant benefit for RT in the POLAR-low group.

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