Therapeutic Treatment With OLX-07010 Inhibited Tau Aggregation and Ameliorated Motor Deficits in an Aged Mouse Model of Tauopathy.

J Neurochem · 2025 · PMC11886763 · PMID 40052227

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Analysis of total tau in the serum by ELISA showed a trend to increase in total tau in the high‐dose group compared to the Vehicle group. 4 Discussion A therapeutic study design was used to evaluate treatment with OLX‐07010 on the accumulation of tau aggregates in an aged mouse model of 4R tauopathy, homozygous female P301L tau JNPL3 mice (Figure 1 ).

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