Comparative effectiveness of netupitant-palonosetron plus dexamethasone versus aprepitant-based regimens in mitigating chemotherapy-induced nausea and vomiting: a meta-analysis of randomized controlled trials.

Oncologist · 2025 · PMC11886791 · PMID 39284781

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Compared with aprepitant, NEPA showed a trend toward being more effective in managing emesis in the delayed phase (RR, 1.16; 95% CI, 0.97--1.39); however, the effectiveness of NEPA and aprepitant did not differ significantly in the overall phase (RR, 1.07; 95% CI, 0.92-1.24) or the acute phase (RR, 1.00; 95% CI, 0.77--1.30; Figure 4 ).

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