Propranolol Reduces Parkinson's Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial.

Ann Neurol · 2025 · PMC11889531 · PMID 39707791

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

approached significancep = 0.09so close (0.05 < p ≤ 0.1)

In the cerebellum, the effect of propranolol approached significance (main effect DRUG: F [1,21] = 3.1; p = 0.09; η p 2 = 0.13).

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a trend toward significanceno p-value reported

Propranolol Inhibits Tremor‐Related Brain Activity Tremor was associated with a cerebral circuit comprising the contralateral motor cortex, ipsilateral cerebellum, and contralateral thalamic VLpv nucleus (exhibiting a trend toward significance).

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