High α-SMA expression in the tumor stroma is associated with adverse clinical parameters in mismatch repair-proficient colorectal cancers only.

In another series of 289 patients with CRC, high mRNA expression levels of α‐SMA showed a trend toward shorter overall survival and a combination of CAF and M2 macrophage mRNA markers: α‐SMA, fibroblast‐specific protein 1, and fibroblast activation protein together predicted the outcome. 29 These suggest that for improved survival prediction, perhaps combinatorial analysis with other markers may prove helpful.

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