Clinical significance of peripheral T-cell repertoire in head and neck squamous cell carcinoma treated with cetuximab and nivolumab.

However, when assessed as a continuous variable, the differences of baseline productive Simpson clonality across response groups did not reach statistical significance (Kruskal–Wallis test, p = 0.35), as shown in Supplementary Fig. 1a.

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Figure 1 b shows an overall trend of decreased TCR diversity (increased Simpson Clonality) across CR/PR/SD/PD groups, which is in line with our earlier study based on the survey-level immunoSEQ from 41 patients.

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Three gene pairs—TRBV7-2/TRBJ2-7, TRBV20-1/TRBJ2-3, and TRBV7-2/TRBJ1-2—emerged as potential prognostic biomarkers, exhibiting significant or marginally significant associations with both therapy response and survival outcomes.

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