Local regulatory variation in Saccharomyces cerevisiae.

These genes were chosen on the basis of showing highly significant self-linkage ( p < 10 −8 ) and at least a 1.2-fold difference in expression between segregants bearing the BY and RM alleles, such that no false positives and only one chance trans linkage due to a nearby gene were expected (see Materials and Methods ).

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Although the linkage study measured expression with microarrays and the ASE measurements were carried out by quantitative PCR, we noted that there was reasonable agreement between linkage results and ASE results in the fold-change estimates for the 44 nominally significant genes ( Figure 1 ).

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