RNAseq gene counts of three class-switching genes ( AICDA , HOXC4 , and RNF8 ) also show a strong trend toward an increase in cis-female compared with cis-male B cells ( Fig. 3, N–P ; Table S2 lists P values for count comparisons of the other genes in this set, as well as their main function[s]).
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Estrogen influences class-switched memory B cell frequency only in humans with two X chromosomes.
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