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Aspirin-triggered DHA metabolites inhibit angiogenesis.

Front Pharmacol · 2025 · PMC11893558 · PMID 40070577

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did not reach statistical significanceno p-value reported
The number of junctions and the total tubule length also showed a tendency to decrease even if the difference did not reach statistical significance with respect to control cells ( Figures 8A, B ). 2.5 Aspirin-triggered DHA metabolites inhibited in vivo angiogenesis To confirm in vitro data, we tested the effect of 17R-HDHA (3 μM) and its downstream metabolite 17R-RvD1 (50 nM) on in vivo angiogenesis using the Matrigel sponge model enriched with SKOV3 ovarian cells.

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