Beta-blocker administration within 24 hours after admission to the intensive care unit and mortality in critical heart failure patients: a retrospective analysis from the MIMIC-IV database.

Front Pharmacol · 2025 · PMC11897012 · PMID 40078276

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0.0580

closest p · 1.2× alpha

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showed a trendp = 0.058so close (0.05 < p ≤ 0.1)

However, after PSM, carvedilol at doses >25 mg/day significantly reduced 30-day (HR = 0.50 95%CI: 0.30, 0.85, p = 0.011) and 360-day all-cause mortality (HR = 0.68 95%CI: 0.49, 0.94, p = 0.020) and showed a trend toward reducing 7-day all-cause mortality (HR = 0.46 95%CI: 0.20, 1.03, p = 0.058), though without statistical significance.

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