Efficacy and safety of novel anticoagulant therapies in patients with chronic kidney disease-a systematic review and meta-analysis.

J Nephrol · 2025 · PMC11903568 · PMID 39614034

Europe PMC DOI

hedged sentences

0.0100

closest p · 0.2× alpha

0.0800

boldest claim

The sentences

highly significantp < 0.01actually significant

The heterogeneity was substantial ( I 2 = 84.9%), with a highly significant test for heterogeneity ( p < 0.01), indicating considerable variability in the effect sizes across the different studies and elucidating the importance of continuing to perform clinical trials that target CKD and ESKD patients, under similar circumstances.

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did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

Although the trend did not reach statistical significance ( p = 0.08), the findings suggest a potential advantage of standard-dose direct oral anticoagulants over warfarin in patients with impaired kidney function, which aligns with our findings [ 73 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.