Barely Significant
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Circulating Blood-Based Proteins in Psychopathology and Cognition: A Mendelian Randomization Study.

JAMA Psychiatry · 2025 · PMC11904806 · PMID 40072421

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hedged sentence
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closest p · 1.0× alpha
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boldest claim

The sentences

nominally significantP<0.05actually significant
To further test for potential pleiotropic effects of non-psychiatric diseases, we performed a phenomewide association study on all nominally significant (P<0.05) SNP instruments within all Bonferroni-significant genes using the IEU OpenGWAS database 16 , 17 , filtered using the keywords “cancer” and “disease.” An extensive literature search was performed to determine potential novelty of significant MR results ( eMethods ).

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