nominally significantP<0.05
To further test for potential pleiotropic effects of non-psychiatric diseases, we performed a phenomewide association study on all nominally significant (P<0.05) SNP instruments within all Bonferroni-significant genes using the IEU OpenGWAS database 16 , 17 , filtered using the keywords “cancer” and “disease.” An extensive literature search was performed to determine potential novelty of significant MR results ( eMethods ).