Peptide-Drug Conjugate for Therapeutic Reprogramming of Tumor-Associated Macrophages in Breast Cancer.

[ 34 ] The mIHC analysis of 4T1.2 tumors revealed a significant increase in CD4 + T cell density in the MACTIDE‐V‐treated group compared to CtrlPep‐V and PBS, an increasing trend in CD8 + T cell density with both conjugates and no differences in Treg density (Figure 7H,I ).

also in 63,971 other papers

A decreasing trend in the immunosuppressive FOXP3 + PD‐1 + population among CD4 + T cells was observed in the MACTIDE‐V treated group compared to the other experimental conditions (Figure 8H ).

also in 47,180 other papers

Although no significant differences were observed in mice survival (Figure S3 , Supporting Information), MACTIDE‐V followed by tumor irradiation slowed down the tumor growth compared to the control groups PBS (+), CtrlPep‐V (‐), CtrlPep‐V (+) and MACTIDE (‐) (“+” denotes irradiated and “‐” denotes non‐irradiated), although these differences did not reach statistical significance.

also in 111,027 other papers