Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis.

At the nominally significant threshold ( P < 0.05), it was also associated with an increased risk of six other gene-specific CH subtypes but a decreased risk of DNMT3A -CH (OR = 0.31, 95% CI = [0.18, 0.55], P = 1.44 × 10 −6 ; Fig. 4b and Supplementary Table 15 ).

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