Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes.

Cancer Res · 2025 · PMC11907192 · PMID 39786467

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Also, all six of the anti-PD-1–treated tumors were diploid, whereas the control antibody–treated tumors showed a trend of increased amount of CNVs compared with anti-PD-1–treated tumors, and 2/6 tumors displayed high level of aneuploidy ( Fig. 5C and D ).

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