Small-scale genetics studies have identified nominally significant loci associated with clozapine-induced myocarditis, 20 and genome-wide significant loci for leukopenia 21 and neutropenia or agranulocytosis. 22 , 23 Finally, a 2022 umbrella review of 10 systematic reviews of the genetic studies of clozapine response 24 concluded findings from most of the studies were inconsistent or negative.
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Clozapine Efficacy and Adverse Drug Reactions Among a Nationwide Study of 1021 Australians Prescribed Clozapine: The ClozaGene Study.
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