DNMT3b-mediated CpA methylation facilitates REST binding and gene silencing and exacerbates hippocampal demyelination in diabetic mice.

Because DNMTs are considered potential REST cofactors, we next examined the expression of MBP, CNTN1, REST, and DNMTs (DNMT1, DNMT3a, and DNMT3b) and found that the expression of REST increased in conjunction with that of DNMT3B and showed a trend opposite to that of MBP, whereas the expression of DNMT1 and DNMT3a was relatively stable ( Fig. 3 , A and B ).

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