Intestinal inflammation marker calprotectin regulates epithelial intestinal zinc metabolism and proliferation in mouse jejunal organoids.

The major stem cell marker Lgr5 was not affected significantly by CP exposure, although it was close to significance, and the effect was confirmed in a subsequent experiment (see Fig. 10B ).

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Reg3g was robustly induced by CP in monolayers, Defa2 levels were lower (the latter did not reach statistical significance), and Alpi was unchanged, as in regular organoids ( Fig. 11 ).

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Pl2g2a exhibited the same trend, but fell short of significance; however, this was confirmed in a later experiment, as also the case with Lyz1 ( Fig. 12 ).

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