Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results.

This revealed an increased baseline infiltration trend with CD68+/CD163+ and CD68+/CD163− TAMs in tumors of patients with the progressive disease compared with tumors of patients with the stable or responsive disease, although it did not reach statistical significance (mean CD68+/CD163− cell density: 0.15 cells/mm 2 , 95%CI [0.06–0.24] in ‘Progressive’; 0.07 cells/mm 2 , 95%CI [0.001–0.13] in ‘Stable+Elite’, P = ns; mean CD68+/CD163+ cell density: 5.1 cells/mm 2 , 95%CI [2.4–7.7] in ‘Progressive’; 2.9 cells/mm 2 , 95%CI [0.54–5.3] in ‘Stable+Elite’, P = ns; Fig. 4a ).

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