Differential efficacy of first licensed western vaccines protecting without immunopathogenesis Wuhan-1-challenged hamsters from severe COVID-19.

NPJ Vaccines · 2025 · PMC11914482 · PMID 40097436

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did not reach statistical significanceno p-value reported

Comirnaty, Jcovden, or Spikevax-immunized animals had comparable mean lung weights between 1.319 g to 1.417 g, while the Vaxzevria cohort revealed a slightly higher mean lung weight of 1.589 g, although this difference did not reach statistical significance.

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nearly reached significanceno p-value reported

1E, F ) and nearly reached significance for the Comirnaty group also in comparison to naïve infected animals.

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