mRNA vaccine-induced SARS-CoV-2 spike-specific IFN-γ and IL-2 T-cell responses are predictive of serological neutralization and are transiently enhanced by pre-existing cross-reactive immunity.

However, over the course of 6 months post-second dose, 111/113 (98.5%) LTCH staff exhibited highly significant decays ( P < 0.0001) in anti-spike and anti-RBD IgG antibody levels with approximate half-lives of 63 (31–73) days and 57 (28–71) days, respectively, ( Fig. 5A through F ).

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Moderate positive correlations approaching significance were additionally observed for spike-specific IL-2 ( r s = 0.4655, P = 0.0515) and dual IFN-γ/IL-2 ( r s = 0.4009, P = 0.0992) T-cell responses ( Fig. 7B ).

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