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Vonoprazan treatment improves gastrointestinal symptoms in patients with gastroesophageal reflux disease.

Kaohsiung J Med Sci · 2017 · PMC11915918 · PMID 29132551

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The rates of improvement and resolution for epigastric pain had a greater trend than for postprandial distress, although it did not reach statistical significance.

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a favorable trendno p-value reported
Vonoprazan also showed a favorable trend in the improvement of lower GI symptoms including constipation and diarrhea in this study.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.