Barely Significant
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The Association of Heterozygous p.R4810K of RNF213 and Long-Term Unfavorable Outcomes after Encephaloduroarteriosynangiosis in Chinese Pediatric Patients with Moyamoya Disease.

Hum Mutat · 2024 · PMC11918495 · PMID 40225941

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an increasing trendno p-value reported
Although there appears to be an increasing trend in the age of onset from AA to GA and GG, the difference is not statistically significant ( Figure 2(a) ).

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Although we observed a trend suggesting a protective effect of early surgery, the results did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.