Soluble Fms-like tyrosine kinase-1 polymorphisms associated with severe-spectrum hypertensive disorders of pregnancy.

Arch Gynecol Obstet · 2025 · PMC11920004 · PMID 39806130

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marginally significantno p-value reported

In the severe-spectrum cohort, a marginally significant protective effect among mothers carrying infants with a single dose of the A allele (rs7993594) was observed (RR = 0.59, 95% CI 0.36, 0.98) and double-dose maternal carriage of the G-t-G-G haplotype increased risk of severe disease (RR = 4.13, 95% CI 1.22, 13.80).

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nominally significantno p-value reported

Results Maternal double dose of the A allele (rs7993594) exhibited a nominally significant increased risk of HDP (RR = 3.52, 95% CI 1.08, 11.20).

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of borderline significanceno p-value reported

Decreased risk was observed in the fetal A allele in SNP rs7983774, though this finding was of borderline significance.

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