Evaluating oxidative stress targeting treatments in <i>in vitro</i> models of placental stress relevant to preeclampsia.

Results Overall, MDA plasma concentration was increased in the preeclampsia group compared to healthy controls (p < 0.001) whereas UA showed a trend towards an increase (p = 0.06); when adjusted for differences in gestational age at blood sampling, MDA remained (p < 0.001) whereas UA became (p = 0.03) significantly correlated with preeclampsia.

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Borderline significance was observed in relation to the metformin-mediated reduction of IL-8 (Rho-6G 101.8 ± 60.49 pg/mL vs.

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Here, we confirmed that following the diagnosis of preeclampsia, UA plasma concentration was increased albeit borderline significant, and this was also reflected in our 2D first trimester trophoblast cell- based in vitro models of placental stress in preeclampsia.

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