Barely Significant
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Digitization of molecular complexity with machine learning.

Chem Sci · 2025 · PMC11922160 · PMID 40115180

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a clear trendno p-value reported
Analysis of FDA-approved drugs from 1985 to 2022 revealed a clear trend toward increasing molecular complexity, reflecting advances in both synthetic techniques and biological targets.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.