Apigenin protects ischemic stroke by regulating intestinal microbiota homeostasis, regulates brain metabolic profile.

Interestingly, although APG treatment led to an increase in ATP levels and a decrease in ATPase levels in comparison to the control group, these changes did not reach statistical significance ( Figures 6D, E , P < 0.05). 3.6 APG improves inflammation and oxidative stress in ischemic stroke The levels of MDA, IL1β, and IL6 were markedly increased, while the activities of SOD and GSH were notably decreased in the ischemic penumbra tissue of the MCAO group in contrast to the control group ( P < 0.05).

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