Exploring the protective effect of metformin against sarcopenia: insights from cohort studies and genetics.

Consistent with previous results, these findings suggest that metformin may be significant value in preventing sarcopenia in T2DM patients.

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While the correlation between GDF15 and lean body mass and fat-free mass did not reach statistical significance, there was a positive trend observed (Figure S2-S3) (Table 2 ), suggesting that GDF15, as a target of metformin, plays a significant role in reducing sarcopenia traits and associated risks.

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