Early and rapid initiation of quadruple therapy for heart failure with reduced ejection fraction: A real-world experience.

There was a trend towards those achieving 4×4 being more likely to reach at least 50% target doses of RAASi at 4 weeks compared to those who did not achieve 4×4, although it did not reach statistical significance (ACEi/ARB/ARNI: 59% [N=23] vs 40% [N=17], p =0.19).

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