Dopamine-driven increase in IL-1β in myeloid cells is mediated by differential dopamine receptor expression and exacerbated by HIV.

Finally, age-related analyses showed a trend in that donors under 50 had a dopamine-mediated increase in IL-1β production, although the dopamine-induced fold change in IL-1β was greatest in donors over 50 (Supplementary Fig. 2D, Wilcoxon tests, Under 50, n = 29, p = 0.0724, sum of (+, −) ranks 301, − 134; Over 50, n = 11, p = 0.5195, sum of (+, −) ranks 41, − 25).

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