Role of the C-terminal domain in modifying pH-dependent regulation of Ca<sub>v</sub>1.4 Ca<sup>2+</sup> channels.

With this analysis, the stronger pH sensitivity of Ca v 1.4 FL was evident as a lower IC 50 for proton inhibition compared to Ca v 1.4Δe47, which did not reach statistical significance for K1591X, and significantly steeper slope than for both variants ( Figure 5c ).

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