showed a trendP = 0.0661
We found that 5 μM colibactin 742 showed a trend toward reduced proliferation in NTC cells ( P = 0.0661) but not PSMD4 −/− cells ( P = 0.9462), and that the proportion of BrdU cells was significantly higher in PSMD4 −/− cells after 1 μM ( P < 0.0001) and 5 μM ( P = 0.0078) colibactin treatment ( Fig.