Gasdermin D deletion prevents liver injury and exacerbates extrahepatic damage in a murine model of alcohol-induced ACLF.

No significant change was observed in the mRNA expression levels of genes related to microglia activation ( Aif1 ) and homeostasis ( P2ry12 and Gpr34 ) ( figure 8B ); however, astrocyte activation was suggested by an increase in the expression of Gfap in GSDM-D KO mice, as well as an increasing trend in the astrocytic glutamate transporter Eaat2 ( figure 8C ).

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Regarding pyroptosis, GSDM-D KO mice undergoing ACLF showed a trend towards a reduced expression of cleaved CASP1 ( figure 4D ) and IL-1β and a significant decrease in IL-18 ( figure 4E ) at the protein level, indicating inhibition of pyroptotic cell death.

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