Connexin 43 is downregulated in advanced Parkinson's disease in multiple brain regions which correlates with symptoms.

Sci Rep · 2025 · PMC11937269 · PMID 40133513

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a slight trendno p-value reported

Despite a slight trend towards elevated Iba1 in the parietal cortex in PD, this parameter only showed a strong correlation with Cx43 puncta loss in the caudate region in the PD cohort and no anti-correlation with Cx43 expression in healthy individuals (Fig. 4 D, Suppl.

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showed a trendno p-value reported

On the other hand, higher Cx43 in the parietal cortex (protein levels) and globus pallidus (puncta) showed a trend towards correlation with aggression (Table 1 ).

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