Leveraging large-scale biobank EHRs to enhance pharmacogenetics of cardiometabolic disease medications.

Nat Commun · 2025 · PMC11937416 · PMID 40133288

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp -value < 2.51e−19actually significant

Association results between TC PRS and TC response to statins were highly significant ( p -value < 2.51e−19) and directionally concordant with LDL-C results.

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nominally significantp -value = 1.84e−03actually significant

SLCO1B1 locus was nominally significant in the UKBB ( p -value = 1.84e−03) and genome-wide significant in the TC response GWAS for which sample size was larger ( p -value = 1.89E−09, baseline adjusted).

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