Oxidized protein aggregate lipofuscin impairs cardiomyocyte contractility via late-stage autophagy inhibition.

Redox Biol · 2025 · PMC11938141 · PMID 40068328

Europe PMC DOI

hedged sentence

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

Additionally, ConA reduced contraction and relaxation velocity and CQ showed a trend towards a decreased contraction velocity (p = 0.08, Fig. 4 e–f). 4 Discussion Our study revealed that aging is associated with functional impairment of cardiomyocytes and accumulation of autofluorescent protein aggregates, such as lipofuscin.

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