Effectiveness of Local Antibiotics for Infection Prevention in Primary Joint Arthroplasty: A Systematic Review and Meta-Analysis.

Antibiotics (Basel) · 2025 · PMC11939600 · PMID 40149026

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

almost reached statistical significancep = 0.059so close (0.05 < p ≤ 0.1)

Powder administration almost reached statistical significance ( p = 0.059) when examining the administration types after excluding intraosseous injection and the study by Abuzaiter et al.

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did not reach statistical significanceno p-value reported

First, the RCT results show that administration of vancomycin powder (RR = 0.37, 95% CI: 0.06–2.47, I 2 = 49%) and bone cement (RR = 0.40, 95% CI: 0.14–1.17, I 2 = 56%) did not reach statistical significance.

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