Previous local bilateral intra-PVN infusion of L -α-aminoadipate ( L -AAA), a gliotoxin that interferes with astrocyte function [ 102 ], significantly ameliorated inflammation-mediated anxiety-like behavior in the EPM test, while relief in the OFT, although observed to some extent, did not reach statistical significance.
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Astrocytes in Rodent Anxiety-Related Behavior: Role of Calcium and Beyond.
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