Prognostic Differences Between Early-Onset and Late-Onset Colorectal Cancer.

Although individuals with EO-CRC exhibited a higher prevalence of distal tumor localization and stenotic macroscopic appearance compared to those with LO-CRC, these differences did not reach statistical significance ( p > 0.05) ( Figure 3 and Table 2 ).

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However, recent epidemiological data indicate a stabilization or even a decline in CRC incidence in developed countries, while an increasing trend has been observed in developing countries [ 4 , 5 ].

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