COVALENCE STUDY: Immunogenicity and Reactogenicity of a COVID-19 mRNA Vaccine in an Open-Label Cohort of Long-Survivor Patients with Metastatic Lung Cancer.

Vaccines (Basel) · 2025 · PMC11946322 · PMID 40266144

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0700

boldest claim

The sentences

highly significantp < 0.0001actually significant

In the overall population, a medium but highly significant correlation (r = −0.31, p < 0.0001) was found between age and the log-transformed values of antibody titres.

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borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

In the univariate regression analysis, the relationship between age and Ab titres was borderline significant (beta = −0.03, p = 0.06), explaining only a very small part of h heterogeneity (r 2 = 0.03).

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a decreasing trendp = 0.07so close (0.05 < p ≤ 0.1)

In the COVID-19-naive patients, when age was categorised in three groups (<60 years, 60–69 years and ≥70 years), no statistical difference was observed ( p = 0.018) but the evidence for a decreasing trend in Ab titres related to an increase in age was borderline significant ( p = 0.07) ( Figure 1 D–F) ( Table S5 ).

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showed a trendno p-value reported

Similar to our findings in patients with NSCLC, other studies also showed a trend in a waning antibody response after booster vaccination in elderly healthy vaccines [ 7 , 9 , 14 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.