Among the severe COVID-19 patients without HSV-1 reactivation, those with bacterial superinfection showed a trend toward higher serum presepsin levels ( Figure 2 c).
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Elevated Serum Presepsin Identifies Herpes Simplex Virus-1 Reactivation in COVID-19 Patients.
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However, after excluding patients with HSV-1 reactivation, presepsin levels in severe COVID-19 patients with bacterial superinfection showed an almost significant increase, aligning with findings in sepsis [ 17 , 18 ].