Sensitivity of Immunodiagnostic Tests in Localized Versus Disseminated Tuberculosis-A Systematic Review of Individual Patient Data.

Regarding the comparison of IGRA results in disseminated versus other forms of tuberculosis, a previous multicenter study using data from collaborators from mainly high-income European countries found that in children with microbiologically confirmed tuberculosis IGRA sensitivity, when results were pooled for different versions of IGRAs ,was 70% (56/79) in those with disseminated versus 89% (283/315) in those with pulmonary tuberculosis, which we calculated was a statistically highly significant difference ( p = 0.00003).

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In a subgroup analysis restricted to patients with microbiologically confirmed tuberculosis, the rate of positive IGRAs was lower in disseminated tuberculosis compared to localized tuberculosis in those from high-income countries but this did not reach statistical significance.

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