Evolutionary divergence in CTCF-mediated chromatin topology drives transcriptional innovation in humans.

Nat Commun · 2025 · PMC11947266 · PMID 40140405

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Notably, although the DNA sequences of the CTCF sites within the PCDH -β locus are identical between humans and macaques, the human CTCF sites within the PCDH -β locus showed a trend of increasing DNA methylation compared to macaques (Fig.

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