Investigating Molecular Mechanisms in Ischemic Preconditioning-Induced Resiliency to Severe Acute Global Cerebral Ischemia Using a Mouse Model of Chronic Cerebral Hypoperfusion.

Males exhibited a highly significant increase in BDNF levels (Fig. 10 A) in the PC group compared to BCCAo ( p < 0.0001).

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In females, the preconditioning group exhibited a trend toward reduced microglial activation, with fewer IBA1-positive cells compared to the BCCAo group, but the difference between the preconditioning and BCCAo groups did not reach statistical significance.

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