2024 EACTS/EACTAIC/EBCP Guidelines on cardiopulmonary bypass in adult cardiac surgery.

One study showed that the use of the Hepcon device resulted in a highly significant reduction in the total protamine dose compared to ACT-based dosing (mean protamine dose: 14.190 IU vs 24.777 IU; P<0.001) and total blood loss (mean blood loss: 804 ml vs 1416 ml; P<0.001). 495 Davidsson et al. performed a study evaluating a statistical model, where the protamine dose was calculate

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Data from an observational cohort 804 from the German Registry for Acute Aortic Dissection Type A, comprising 2100 patients, showed a trend towards a reduction in 30-day mortality associated with the use of mannitol; however, this trend was not statistically significant.

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