Targeting of phosphorylated tau at threonine 181 by a Qβ virus-like particle vaccine is safe, highly immunogenic, and reduces disease severity in mice and rhesus macaques.

In a separate, larger cohort of PS19 mice immunized with pT181‐Qß following the same paradigm, we again observed significant reduction in AT180 positive (pT231 + ) pTau and total human tau (Tau12 + ), with nearly significant reduction in AT8 positive tau ( p = 0.07) and a significant increase in Tau5 + endogenous mouse tau (Figure S1 ).

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