L-arginine dependence of breast cancer - molecular subtypes matter.

3 c), but we found a highly significant association between high L-citrulline concentration and shorter survival time in patients with triple-negative breast cancer (HR = 8.18 (1.33–21.48); N = 36; p = 0.018; Fig. 3 d).

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Concentrations of L-arginine-related metabolites in women with breast cancer In a statistical model including age as a co-variate, the plasma concentrations of L-arginine and L-citrulline were not significantly different between patients and controls; however, L-ornithine concentration showed a trend to be higher in patients than in controls (Table 3 ).

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