Effects of sotagliflozin on kidney and cardiac outcome in a hypertensive model of subtotal nephrectomy in male mice.

Moreover, the incidence of the composite kidney end point of a sustained ≥50% decrease in eGFR, sustained eGFR of <15 mL/min per 1.73 m 2 , dialysis, or kidney transplant was reduced by 29% in the SCORED trial, albeit this did not reach statistical significance (Bhatt, Szarek, Pitt, et al., 2021 ).

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The latter was associated with a nonsignificant trend for a greater % area of left ventricular fibrosis staining (Figure 4e ). 3.3.

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